COL4A1 with Cerebral Small Vessel Disease and Multiple Anomalous cerebral vascular origins: A case report

Cerebral small vessel disease (cSVD) is a main cause of stroke, cognitive impairment, and vascular dementia. COL4A1 mutations have been identified as hereditary cerebral disease. mutation associated with nephropathy, aneurysms, muscle cramps, which we call the HANAC syndrome. Mutations in recently both mouse model families, characterized by cystic brain cavities white-matter lesions. But it has not reported malformations. We here first report case multiple anomalous origins.